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Amyloidosis is a disease that occurs when substances called amyloid proteins build up in your organs. It is an abnormal protein usually produced by cells in your bone marrow that can be deposited in any tissue or organ. It can affect different organs in different people. It frequently affects the heart, liver, spleen Ryan Hartman Youth Jersey , kidneys, nervous system and gastrointestinal tract.
They depend on which of your organs are affected.
• Swelling of your ankles and legs
• Significant weight loss
• Shortness of breath
• Numbness in your hands or feet
• Diarrhea or constipation
• Feeling full quickly
• Severe fatigue
• An enlarged tongue (macroglossia)
• Skin changes, such as thickening or easy bruising
• Purplish patches (purpura) around the eyes
• An irregular heartbeat
• Difficulty swallowing
• Protein in the urine (detected by urine tests)
• Primary: This most common form can affect many areas, including your intestines, kidneys Brandon Saad Youth Jersey , heart, spleen, nerves, skin, liver Artem Anisimov Youth Jersey , tongue and blood vessels. It isn't associated with other diseases. The exact cause of it is unknown.
• Secondary: This form occurs in association with chronic infections or inflammatory diseases, such as inflammatory arthritis or osteomyelitis, tuberculosis, a bone infection. It primarily affects your kidneys, liver and lymph nodes Richard Panik Youth Jersey , spleen, though other organs may be involved. Treatment of this disease may help stop progression of this form.
• Hereditary (familial): As the name implies, this form is inherited. This type often affects the nerves, liver, kidney and heart.
• Dialysis-related (DRA). This form develops when proteins in blood are deposited in joints and tendons Alex DeBrincat Youth Jersey , causing stiffness pain.
• Age: The majority of people who develop this are older than 60.
• Other diseases: You may be at increased risk if you have a chronic infection or inflammatory disease. People who have multiple myeloma — a form of bone marrow cancer — are also at increased risk of this.
• Family history: Some cases of it are inherited.
• Kidney dialysis: If you have kidney disease which requires kidney dialysis, you have an increased risk of it.